Nestled on a street that's been home to some of the area's most important people since the Renaissance, the D.O.M. Hotel Roma offers a bridge between the old and new — not to mention an excellent night's stay. The 24-room hotel boasts glimpses at some of the original elements of the 17-century convent which it now occupies, including exposed brick walls, wooden ceilings, and blocks of marble with ancient religious inscriptions. But it mixes those with sleek furnishings, a lounge, a bistro-style restaurant complete with three original Warhol silkscreens, and a rooftop terrace bar.