The rooms at Endémico — or Encuentro Guadalupe, as it's now called — may be small, but once you get an eyeful of the views they provide, their size simply won't matter. Set on a hill overlooking the Valle de Guadalupe wine region, this unique luxury hotel features 20 luxury cabins, each of which provides unobstructed views of the valley. The hotel is somewhat remote, but thanks to an on-site pool, restaurant, and bar, there's little reason to leave — and since it's just 90 minutes from San Diego, you won't have far to go when you do decide to leave.