The Queen City is full of great museums, so it only makes sense that it's also home to the 21c Museum Hotel Cincinnati. Like its sister hotel in Louisville, the 21c in Cincy is both an outstanding hotel and an art museum, playing host to a number of rotating exhibits in its two-story gallery that's conveniently open 24/7. As for the rooms, there are a number of options, ranging from the Deluxe King all the way up to the spacious Corner Suite, but all of them offer contemporary styling, comfortable beds, custom furnishings, sleek bathrooms, and whimsical touches. Don't forget the eating and drinking options, which include Metropole — one of the city's best restaurants, named after the former Metropole Hotel that occupied the space — and the seasonal Cocktail Terrace, which offers terrific views from its 11th floor rooftop perch. Oh, and keep an eye out for the roaming yellow penguins.